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Application of photon correlation spectroscopy as a technique for detecting culture contamination
Author(s) -
Jepras R. I.,
Perkins E. A.,
Rarity J.,
Carr R. J. G.,
Clarke D. J.,
Atkinson T.
Publication year - 1991
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260380814
Subject(s) - contamination , spectroscopy , particle size , photon , particle (ecology) , population , correlation , biological system , chemistry , analytical chemistry (journal) , materials science , physics , biology , environmental chemistry , optics , mathematics , ecology , demography , geometry , quantum mechanics , sociology
The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydisparity of actively growing and dividing microbial cells negates any advantage in the use of multi‐angle PCS to detect contaminants.