The large‐scale immobilization of  Penicillium chrysogenum : Batch and continuous operation in an air‐lift reactor | Zendy

Keshavarz T. | Zendy; Eglin R. | Zendy; Walker E. | Zendy; Bucke C. | Zendy; Holt G. | Zendy; Bull A. T. | Zendy; Lilly M. D. | Zendy

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The large‐scale immobilization of Penicillium chrysogenum : Batch and continuous operation in an air‐lift reactor

Author(s) -

Keshavarz T.,

Eglin R.,

Walker E.,

Bucke C.,

Holt G.,

Bull A. T.,

Lilly M. D.

Publication year - 1990

Publication title -

biotechnology and bioengineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.136

H-Index - 189

eISSN - 1097-0290

pISSN - 0006-3592

DOI - 10.1002/bit.260360802

Subject(s) - penicillium chrysogenum , industrial fermentation , penicillin , chemistry , bioreactor , lift (data mining) , chromatography , biochemistry , fermentation , organic chemistry , antibiotics , computer science , data mining

A temperature‐sensitive cell division cycle mutant of Penicillium chrysogenum P2 has been immobilized on Celite and grown in a 250–320‐L working volume air‐lift fermenter. The ability to uncouple growth and penicillin synthesis by raising the temperature to 30 °C also overcame the problem of the free cell mass which appeared after 300 h operation with the parent organism. After 500 h operation, penicillin and ACV dimer were still being synthesized.

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