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Hollow fiber supported gas membrane for in situ removal of ammonium during an antibiotic fermentation
Author(s) -
Hecht V.,
Bischoff L.,
Gerth K.
Publication year - 1990
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260351012
Subject(s) - stripping (fiber) , ammonium , microporous material , chemistry , mass transfer , membrane , fermentation , hollow fiber membrane , fiber , chromatography , in situ , materials science , biochemistry , organic chemistry , composite material
To study the influence of ammonium on an antibiotic cultivation, mass transfer measurements of ammonium through microporous hydrophobic membranes using different stripping methods were carried out and compared. The higher overall mass transfer coefficients for ammonium were obtained with an acid stripping solution compared to water, vacuum, or sweeping air. A hollow fiber module for in situ removal of ammonium during cultivation was designed and operated in an external bypass to a 10‐L fermentor. Compared to a control fermentation, the cell dry mass could be increased 2.6 times and the antibiotic concentration 8 times, if the in situ ammonium removal was in operation.