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On‐line optimization of biotechnological processes: I. Application to open algal pond
Author(s) -
Guterman H.,
BenYaakov S.
Publication year - 1990
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260350409
Subject(s) - simplex algorithm , simplex , computer science , software , line (geometry) , process engineering , mathematical optimization , function (biology) , biological system , biochemical engineering , algorithm , mathematics , linear programming , engineering , geometry , evolutionary biology , biology , programming language
A new on‐line optimization and control procedure applicable to biotechnological systems for which a precise mathematical model is unavailable has been developed and tested. The proposed approach is based on an online search for optimum operating conditions by an automatic system using a modified simplex algorithm to which several features have been added to permit real time operation. The simplex algorithm is the upper level of a hierarchical software package in which the other levels are cost evaluation, control, data acquisition, and signal processing. The optimization method was tested in a laboratory minipond for the cultivation of Spirulina platensis . The controlled parameters were light intensity, optical density, pH, and temperature. The proposed optimization method can be applied to other biological processes provided that the pertinent variables can be measured and controlled and the cost function can be defined mathematically.