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Prediction of diffusion coefficients of proteins
Author(s) -
Tyn Myo T.,
Gusek Todd W.
Publication year - 1990
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260350402
Subject(s) - radius of gyration , diffusion , hydrodynamic radius , correlation , radius , stokes radius , statistical physics , chemistry , correlation coefficient , biological system , thermodynamics , physics , mathematics , statistics , geometry , polymer , computer science , biology , biochemistry , computer security , organic chemistry , aqueous solution , micelle , enzyme , size exclusion chromatography
A correlation for predicting the diffusion coefficients of proteins at standard conditions is proposed by adapting the Stokes‐Einstein equation to a model for the equivalent hydrodynamic sphere. The radius of gyration, which accounts for the size and shape of protein molecules in solution, was used in deriving the new correlation. The correlation successfully predicted the diffusion coefficients of proteins, for which experimental data were available, with a higher degree of accuracy than achieved by previous correlation methods.