Premium
Periodic operation of a continuous culture of Baker's yeast
Author(s) -
Abulesz EM.,
Lyberatos G.
Publication year - 1989
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260340603
Subject(s) - dilution , biomass (ecology) , productivity , yeast , steady state (chemistry) , chemostat , saccharomyces cerevisiae , growth rate , transient (computer programming) , biological system , biology , food science , chemistry , microbiology and biotechnology , mathematics , biochemistry , ecology , economics , computer science , thermodynamics , physics , genetics , geometry , macroeconomics , operating system , bacteria
The possibility of enhancing the biomass productivity of a continuous culture of Saccharomyces cerevisiae growing on a glucose‐limited medium is addressed. An unstructured Monod‐type model is first identified using steady‐state data. The culture is subjected to step changes in dilution rate, and it is seen that the Monod model is unable to predict even qualitatively the dynamic response of the culture. Incorporation of a time delay allows significant improvement in the transient fit. It is found that the culture has a time lag of about 3 h in adapting its growth rate. Cycling the dilution rate with a period of 3 h leads to substantial improvement in the average biomass productivity.