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Protein partitioning in two‐phase aqueous polymer systems
Author(s) -
Baskir Jesse N.,
Hatton T. Alan,
Suter Ulrich W.
Publication year - 1989
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260340414
Subject(s) - polymer , aqueous solution , phase (matter) , chemistry , work (physics) , biological system , aqueous two phase system , materials science , organic chemistry , thermodynamics , biology , physics
Theories of protein partitioning in two‐phase polymer systems which account for the effects of different aspects of system composition—such as the choice of materials, protein size, polymer molecular weight, polymer concentration, salt concentration, and affinity ligands—are reviewed. Although the present models provide some information about specific aspects of partitioning, a comprehensive and fundamental theory which can be used to predict protein partitioning behavior has not yet been developed. Some recommendations for future work are given.