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Analysis of a framework using material balances in metabolic pathways to elucidate cellular metabolism
Author(s) -
Niranjan S. C.,
San KaYiu
Publication year - 1989
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260340409
Subject(s) - extracellular , cellular metabolism , metabolic pathway , metabolism , intracellular , metabolic network , chemistry , metabolic rate , computational biology , biology , biophysics , biochemistry , biological system , microbiology and biotechnology , endocrinology
A framework using material balances in metabolic pathways to study cellular metabolism is examined and the results are discussed. Rate measurements on extracellular compounds alone were found to be not always sufficient to validate proposed unique intracellular mechanisms. The conditions to delineate among candidate mechanisms based solely on extracellular measurements are established. The number of half reactions comprising the reaction network is found to be an important parameter.