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Diffusivity of oxygen into carriers entrapping whole cells
Author(s) -
Sun Yan,
Furusaki Shintaro,
Yamauchi Aizo,
Ichimura Kunihiro
Publication year - 1989
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260340107
Subject(s) - thermal diffusivity , oxygen , chemistry , partition coefficient , membrane , chromatography , analytical chemistry (journal) , chemical engineering , thermodynamics , organic chemistry , biochemistry , physics , engineering
The effective diffusivity of oxygen, D e , in Ca‐alginate and PVA–SbQ gels was measured using a two‐chamber vessel with a membrane between the two chambers. The effect of cell density, C c , on D e in Ca‐alginate gels was studied. The effective diffusivity of oxygen decreased with increasing cell density, to C c = 170 kg dry cells/m 3 gel. The dependency of D e on cell density was discussed in terms of a random‐pore model. The model correlated well with experimental data, i.e., kD e / D 0 = 0.86(1 − 1.47 × 10 −3 C c ) 2 . Here, k is the partition coefficient, and D 0 is diffusivity in water.