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Dynamic modeling of immobilized cell reactor: Application to ethanol fermentation
Author(s) -
Nakasaki Kiyohiko,
Murai Takeji,
Akiyama Tetsuo
Publication year - 1989
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260331014
Subject(s) - substrate (aquarium) , chemistry , fermentation , bioreactor , ethanol , diffusion , chemical engineering , chromatography , continuous stirred tank reactor , steady state (chemistry) , ethanol fermentation , continuous reactor , product inhibition , materials science , catalysis , thermodynamics , organic chemistry , oceanography , physics , engineering , geology , non competitive inhibition , enzyme
A mathematical model has been developed for the unsteady‐state operation of an immobilized cell reactor. The substrate solution flows through a mixed‐flow reactor in which cells immobilized in gel beads are retained. The substrate diffuses from the external surface of the gel beads to some internal location where reaction occurs. The product diffuses from the gel beads into liquid medium which flows out of the reactor. The model combines simultaneous diffusion and reaction, as well as cell growth, and it can predict how the rates of substrate consumption, product formation, and cell growth vary with time and with initial conditions. Ethanol fermentation was chosen as a representative reaction in the immobilized cell reactor, and numerical calculations were carried out. Excellent agreement was observed between model predictions and experimental data available in the literature.