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Theoretical study of tryptophan operon: Application in microbial technology
Author(s) -
Sinha Somdatta
Publication year - 1988
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260310204
Subject(s) - trp operon , tryptophan , operon , lac operon , l arabinose operon , yield (engineering) , biochemistry , chemistry , gal operon , amino acid , biological system , biology , stability (learning theory) , computational biology , biochemical engineering , genetics , gene , computer science , physics , recombinant dna , engineering , thermodynamics , escherichia coli , machine learning
A model for the tryptophan operon is formulated based on the genetic and biophysical data available on the structure of the operon and the nature of interactions between the represser and its ligands. Studies have been done, on wild‐type, superrepressing, and loose‐binding strains to identify conditions at which the stability of the system changes (i.e., evolves to a stable synthesis or periodic synthesis with increasing amplitude). Also, the factors that increase the yield of tryptophan are studied and predictions made, based on the results, for obtaining overproducing strains of tryptophan that can be used for the industrial production of this useful amino acid.