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Pilot‐plant production of prednisolone using calcium alginate immobilized Arthrobacter simplex
Author(s) -
Kloosterman J.,
Lilly M. D.
Publication year - 1986
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260280913
Subject(s) - calcium alginate , arthrobacter , calcium , chemistry , simplex , production (economics) , pulp and paper industry , prednisolone , chromatography , biochemistry , organic chemistry , mathematics , engineering , enzyme , medicine , economics , geometry , surgery , macroeconomics
The maximum conversion of hydrocortisone suspensions at initial substrate concentrations greater than 4 g/L by immobilized Arthrobacter simplex in a batch reactor was 80–85%. By feeding hydrocortisone suspensions continuously to either a fed‐batch‐operated stirred tank reactor or to a continuous‐flow airlift loop reactor, at a rate such that the soluble hydrocortisone concentration in the reactor remained ca. 0.05 g/L, 95% conversion of substratewas obtained at final product concentrations exceeding 4 g/L.