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Immobilized cell cross‐flow reactor
Author(s) -
Chotani G. K.,
Constantinides A.
Publication year - 1984
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260260304
Subject(s) - bioreactor , plug flow , residence time distribution , plug flow reactor model , dispersion (optics) , chemistry , materials science , flow (mathematics) , residence time (fluid dynamics) , chemical engineering , chromatography , continuous stirred tank reactor , mechanics , physics , geotechnical engineering , organic chemistry , optics , engineering
A cross‐current flow reactor was operated using sodium alginate gel entrapped yeast cells under growth conditions. Micron‐sized silica, incorporated into the biocatalyst particles (1 mm mean diameter) improved mechanical strength and internal surface adhesion. The process showed decreased productivity and stability at 35°C compared to the normal study done at 30°C. The increased number of cross flows diminish the product inhibition effect. The residence time distribution shows that the cross‐flow bioreactor system can be approximated to either a train of backmixed fermentors in series or a plug flow fermentor with moderate axial dispersion.