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Mass‐energy balance for microbial product synthesis—biochemical and cultural aspects
Author(s) -
Minkevich I. G.
Publication year - 1983
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260250509
Subject(s) - dilution , productivity , biomass (ecology) , yield (engineering) , substrate (aquarium) , energy balance , energy consumption , anaerobic exercise , chemistry , process (computing) , product (mathematics) , biochemical engineering , biochemistry , pulp and paper industry , biology , mathematics , ecology , thermodynamics , economics , physiology , computer science , physics , engineering , macroeconomics , operating system , geometry
Interrelations between the rates of the product synthesis, cell biomass growth, respiration, and organic substrate consumption have been studied by the mass‐energy balance method. This method is based on the utilization of a special unit of substance reducity, namely redoxon. Biochemical parameters have been found which are involved in these interrelations and which describe the processes of high‐energy bond gain and energy expenditure during metabolism. In order to find these, the separation of the whole metabolism into several partial metabolisms has been applied. Equations have been obtained describing the dependences of the product yield and process specific productivity on the biochemical parameters and two macroscopic rates (e.g., rates of dilution and substrate consumption). Both aerobic and anaerobic product syntheses have been considered. The estimate of the upper limit of process productivity has been obtained. Mechanisms of the influence of the producer's intracellular characteristics on the rates of physiological processes and the culture productivity are discussed.