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Identification of mass‐transfer parameters and process simulation of SCP production process in airlift tower reactors with an external loop
Author(s) -
Luttmann R.,
Buchholz H.,
Zakrzewski W.,
Schügerl K.
Publication year - 1982
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260240406
Subject(s) - tower , mass transfer , loop (graph theory) , airlift , process (computing) , bioreactor , process engineering , identification (biology) , production (economics) , mechanics , control theory (sociology) , chemistry , chromatography , engineering , computer science , physics , mathematics , biology , control (management) , botany , structural engineering , combinatorics , organic chemistry , operating system , macroeconomics , artificial intelligence , economics
A distributed parameter model for simulation of SCP‐production processes in tower reactors with an outer loop was developed by considering substrate, cell, and CO 2 balances in the liquid phase, and O 2 and CO 3 balances in the ges phase and taking into account variations of dissolved oxygen concentration, pressure, and k L a along the column, as well as double substrate Monod kinetics. This model was used to describe the cultivation of Hansenula polymorpha in a tower‐loop reactor (height 275 cm, diameter 15 cm). Parameter identification and process simulation were carried out by a hybrid computer. The variation of identified mass transfer parameters with fermentation time and operation mode is considered employing ethanol and glucose substrate, respectively. Relationships among k L a , substrate concentration, and superficial gas velocity were developed to facilitate the layout and simulation of pilot‐plant reactors.