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Microbial transformation of racemic hydantoins to D ‐amino acids
Author(s) -
Olivieri R.,
Fascetti E.,
Angelini L.,
Degen L.
Publication year - 1981
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260231002
Subject(s) - amino acid , transformation (genetics) , hydrolysis , biocatalysis , biotransformation , chemistry , stereospecificity , penicillin , organic chemistry , stereochemistry , biochemistry , enzyme , catalysis , antibiotics , reaction mechanism , gene
It has been shown that resting cells of Agrobacterium radiobacter catalyze a sequence of two stereospecific hydrolytic reactions leading to the complete transformation of racemic hydantoins to D ‐amino acids. This report describes some properties of this new biocatalyst and its potential application for the production of some D ‐amino acids, which are used as intermediates in the preparation of semisynthetic penicillin and cephalosporins.