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Multiple steady‐state phenomena within enzyme reactors: The enzyme reaction with two substrates
Author(s) -
Webster Ian A.,
Shuler Michael L.
Publication year - 1981
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260230504
Subject(s) - isothermal process , steady state (chemistry) , dimensionless quantity , plug flow , continuous stirred tank reactor , work (physics) , thermodynamics , substrate (aquarium) , plug flow reactor model , chemistry , reaction rate , transient (computer programming) , volumetric flow rate , flow (mathematics) , continuous reactor , mechanics , physics , catalysis , biochemistry , oceanography , computer science , geology , operating system
The theoretical dynamic characteristics of an isothermal continuous flow stirred tank enzyme reactor (CFSTER) operating on two substrates are investigated. Under certain conditions multiple steady states are possible; namely, with an enzyme which binds with the two substrates sequentially. The occurrence of multiple steady states is found to be primarily dictated by three dimensionless parameters which incorporate rate law constants. The global stability of certain steady states is examined by numerically solving the transient material balance on the CFSTER. The effect of recycle on the dynamics of an isothermal plug flow enzyme reactor (PFER) is also studied. A general conclusion indicated by this work is that any open isothermal reaction system wherein the reaction rate law passes through a maximum with increasing substrate concentration and where back mixing occurs with exhibit multiple steady‐state behavior in some operating range.