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Enhanced product formation in continuous fermentations with microbial cell recycle *
Author(s) -
Bull Daniel N.,
Young Mark D.
Publication year - 1981
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260230212
Subject(s) - sorbitol , chemostat , fermentation , sorbose , chemistry , serratia marcescens , food science , yeast , biochemistry , chromatography , biology , bacteria , fructose , escherichia coli , genetics , gene
The effect of partial recycle of microbial cells on the operation of a chemostat has been investigated for two fermentations. Stable steady states without partial cell recycle were obtained for the conversion of D ‐sorbitol to L ‐sorbose by Gluconobacter oxydans subsp. suboxydans 1916B and for the conversion of glucose to 2‐ketogluconic acid by Serratia marcescens NRRL B‐486. The employment of partial cell recycle dramatically increased product formation rates for both fermentations.