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Fermentation of Bacillus thuringiensis for exotoxin production: Process analysis study
Author(s) -
Holmberg Andrea,
Sievänen Risto,
Carlberg Gunnel
Publication year - 1980
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260220812
Subject(s) - bacillus thuringiensis , aeration , exotoxin , fermentation , microbiology and biotechnology , serratia marcescens , food science , substrate (aquarium) , bacillales , biology , bacillaceae , chemistry , bacteria , bacillus subtilis , biochemistry , toxin , ecology , escherichia coli , genetics , gene
The exotoxin produced by certain serotypes of Bacillus thuringiensis was used as a means of microbiological control of the larval development of flies. The optimal batch cultivation conditions with respect to pH, temperature, aeration, agitation, and initial concentration of growth‐limiting substrate were determined. A dynamic model describing the process was designed and fitted to the experimental data. The application of a method for estimating exotoxin and bacterial concentrations from on‐line measurable quantities such as oxygen consumption and heat production is presented.