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Mathematical model for enzymatic hydrolysis and fermentation of cellulose by Trichoderma
Author(s) -
Peitersen Nicolai,
Ross Edward W.
Publication year - 1979
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260210606
Subject(s) - trichoderma reesei , cellobiose , cellulose , cellulase , hydrolysis , fermentation , chemistry , enzymatic hydrolysis , enzyme , biochemistry , organic chemistry
This paper describes a mathematical model for the enzymatic hydrolysis and fermentation of cellulose by Trichoderma reesei . The principal features of the model are the assumption of two forms of cellulose (crystalline and amorphous), two sugars (cellobiose and glucose), and two enzymes (cellulase and β‐glucosidase). An inducer–repressor–messenger RNA mechanism is used to predict enzyme formation, and pH effects are included. The model consists of 12 ordinary differential equations for 12 state variables and contains 38 parameters. The parameters were estimated from four sets of experimental data by optimization. The results appear satisfactory, and the computer programs permit simulation of a variety of system changes.