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Design of scraped tubular fermentors
Author(s) -
MooYoung M.,
Van Dedem G.,
Binder A.
Publication year - 1979
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260210406
Subject(s) - aeration , catabolite repression , fermentation , biology , chemistry , biochemistry , ecology , mutant , gene
Conventional stirred‐tank fermentors are inefficient in carrying out certain fermentation processes because of one or more of the following constraints: media backmix–flow, solids wall–deposits, microbial growth–disruption. Two series of novel design of aerated scraped tubular fermentors have been developed to over come the deleterious effects of these constraints. One design is based on a horizontal tube fitted with an internal mechanical wall‐scraper that also promotes media segregation; the other design is based on a vertical array of vessels interconnected by small gas‐jetting orifices that promote media segregation and clean‐surface operation. Tests with cultures of Trichdorma viride (for single‐cell protein production) and Candida lipolytica (for lipase production) have been carried out. It is shown that these novel fermentors can minimize the effects of catabolite repression inherent in both cultures and of wall growth in the former.