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Effect of immobilized enzyme deactivation in fixed‐ and fluid‐bed reactors
Author(s) -
Sadana Ajit
Publication year - 1978
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260200602
Subject(s) - dimensionless quantity , immobilized enzyme , yield (engineering) , substrate (aquarium) , chemistry , diffusion , chromatography , bioreactor , enzyme , continuous reactor , chemical engineering , thermodynamics , catalysis , organic chemistry , physics , oceanography , engineering , geology
Abstract A two‐parameter theoretical model is developed to evaluate the effect of immobilized enzyme deactivation on substrate conversion in fixed‐ and fluid‐bed reactors under diffusion‐free conditions. The method describes a simple reaction in which three different immobilized enzyme deactivation forms are considered, and an expression is developed to evaluate the effect of immobilized enzyme deactivation on yield in a consecutive reaction. Comparison of reactor performances for the two reactor types reduces to a comparison of the appropriate dimensionless parameters. The practical implications of the development are illustrated through an example.