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Considerations in predicting phenotypic modifications in amino acid profiles of total cell protein of microorganisms
Author(s) -
Alroy Yair,
Tannenbaum Steven R.
Publication year - 1977
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260190805
Subject(s) - amino acid , cell , microorganism , biochemistry , function (biology) , biology , amino acid residue , complete protein , cell function , cell size , protein biosynthesis , chemistry , microbiology and biotechnology , bacteria , peptide sequence , genetics , gene
A mathematical model is presented that describes the concentration of an amino acid in total cell protein as a function of its concentration in individual cell proteins or in sets of cell proteins. The resulting equation makes it possible to calculate how the makeup of cell proteins must change to obtain a specified alteration in the content of an amino acid in the total cell protein. It is recognized that protein species or sets of proteins that are distinguished by being richer or poorer in a key amino acid than the overall protein must undergo considerable variations in content. The necessary extent of these shifts suggests that the amino acid composition of total cell protein is not likely to be affected significantly by variations in the cultivation conditions.