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Computation of the fraction of induced cells in enzyme induction systems
Author(s) -
Von Stockar Urs,
Yang Ren Der,
Wilke Charles R.
Publication year - 1977
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260190402
Subject(s) - trichoderma viride , cellulase , fermentation , computation , enzyme inducer , biological system , enzyme , fraction (chemistry) , cellulose , chemistry , enzyme assay , biochemistry , biology , chromatography , food science , computer science , algorithm
A theoretical model is developed for continuous multistage enzyme production systems, which consist of a growth fermentor used for growing microorganisms rapidly without enzyme production and a subsequent system of induction reactors in which enzymes induction and production occurs. The model allows the computation of the fraction of induced cells residing in the induction reactor for organisms exhibiting a lag phase in enzyme induction. For this model a general analytical solution was obtained for the cumulative internal residence time distribution of a series of n well‐stirred vessels with a recycle. The theoretical results are compared in a preliminary way with experimentally measured cellulase productivities of continuous multistage cellulose fermentations with Trichoderma viride QM 9414.