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Computer‐aided material balancing for prediction of fermentation parameters
Author(s) -
Cooney Charles L.,
Wang Henry Y.,
Wang Daniel I. C.
Publication year - 1977
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260190106
Subject(s) - fermentation , biomass (ecology) , process engineering , yield (engineering) , carbon dioxide , biochemical engineering , substrate (aquarium) , biological system , environmental science , computer science , chemistry , pulp and paper industry , materials science , engineering , food science , biology , composite material , ecology , organic chemistry
Despite the importance of biomass as a parameter in fermentation processes, there are no commercially available sensors suitable for its measurement. An indirect approach for the assessment of biomass concentration can be based on material balances and on the direct monitoring of fermentation parameters for which there are established sensors (e.g., gaseous oxygen and carbon dioxide). As a consequence, this method requires no assumption of cellular yield coefficients or rate constants. This approach is also readily adaptable to general use since it requires only some knowledge of the compositions of the substrate, cells, and noncellular products.