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An automatic apparatus for continuous suspension culture with a concentrating device
Author(s) -
Schmialek P.,
Geyer Astrid,
Miosga Verena,
Nündel M.,
Zapf B.
Publication year - 1976
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260181102
Subject(s) - chemostat , suspension culture , suspension (topology) , cell culture , bioreactor , process engineering , biochemical engineering , biological system , chemistry , materials science , computer science , biology , engineering , mathematics , bacteria , genetics , homotopy , pure mathematics , organic chemistry
A chemostat in which mammalian cells can be raised in continuous suspension culture is described. It is constructed from commercially available parts. This apparatus has the advantage over earlier models in that the medium can be pumped off free of cells, thus suddenly increasing the cell concentration in the culture. The apparatus has been successfully used in studies on contact inhibition.