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Variable‐volume continuous cultivation
Author(s) -
Dunn I. J.,
Mor J.R
Publication year - 1975
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260171210
Subject(s) - volume (thermodynamics) , chemostat , variable (mathematics) , steady state (chemistry) , bioreactor , constant (computer programming) , state variable , continuous flow , process engineering , mathematics , control theory (sociology) , biochemical engineering , computer science , thermodynamics , chemistry , engineering , physics , biology , mathematical analysis , genetics , control (management) , organic chemistry , artificial intelligence , bacteria , programming language
Equations are developed which describe variable‐volume cultivations, including fed‐batch systems. An analogy is drawn between the quasi‐steady state in variable‐volume cultivation and a dynamic steady state in variable‐flow, constant‐volume chemostat bioreactors. Switching procedures are developed to give a steady‐state transition from batch to fed‐batch and to continuous operation. In this respect, considerations in the literature have been extended. Computer solutions of the governing differential equations verify the theory and provide insight into the behavior of variable‐volume stirred tank reactors. Application of variable‐volume cultivation as a tool in investigating growth rates at low substrate levels is suggested. Variable‐volume bioreactor systems could be also to obtain controlled dynamic conditions for research or production purposes.