Premium
Isolation of a cyclitol antibiotic: 2,3,4,5‐tetrahydroxycyclohexanemethanol
Author(s) -
Miller T. W.,
Arison B. H.,
AlbersSchonberg G.
Publication year - 1973
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260150606
Subject(s) - isolation (microbiology) , cyclitol , chemistry , fermentation , yield (engineering) , bacteria , chromatography , stereochemistry , organic chemistry , biochemistry , microbiology and biotechnology , biology , materials science , receptor , inositol , metallurgy , genetics
The isolation and structure determination of a new microbial product, (+)‐ (123/45)‐2,3,4,5‐tetrahydroxy‐1‐cyclohexanemethanol is described. This product was detected in the fermentation broth of a newly isolated actinomycete by its antibacterial activity. A novel isolation method was developed and crystalline product was obtained in good yield. The structure was determined by spectroscopic examination of the product and its acetyl and trimethylsilyl derivatives. The racemic form of this compound had already been synthezised by G. E. McCasland et. al., as analog of galactose.