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Growth and acid production by Lactobacillus (L.) delbrueckii in a dialysis culture system
Author(s) -
Friedman Morton R.,
Gaden Elmer L.
Publication year - 1970
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260120608
Subject(s) - lactic acid , dialysis , dialysis tubing , lactobacillus , chemistry , biochemistry , lactobacillaceae , bacteria , biology , medicine , fermentation , genetics , membrane
Growth and lactic acid production by L. delbrueckii was studied in a dialysis culture system and the inhibitory effect of lactate confirmed by removing lactate from the culture medium by dialysis. It has been shown that lactate inhibits growth after the log phase and that the maintenance of low lactate concentrations after this point permits higher specific growth rates and higher maximum cell concentrations. Acid production is also significantly higher in a dialysis culture system. Finally, a modification of the Luedeking‐Piret model, incorporating the lactate inhibition effect, is proposed.