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A continuous, multistage tower fermentor. II. Analysis of reactor performance
Author(s) -
Falch Edvard A.,
Gaden Elmer L.
Publication year - 1970
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260120311
Subject(s) - residence time distribution , backflow , tower , cascade , continuous stirred tank reactor , flow (mathematics) , mechanics , mathematics , fermentation , biological system , process engineering , computer science , chromatography , chemistry , engineering , mechanical engineering , physics , structural engineering , chemical engineering , food science , inlet , biology
A method for analyzing the reactor behavior of a continuous, multistage tower fermentor is described. A model consisting of a system of interconnected, ideal subreactors is set up on the basis of the fermentor's configuration and flow pattern. The residence time distribution curve is used to test the validity of the model and the relative quantities of flow streams and regions in the model are determined. A least‐square fitting procedure between measured and calculated distribution curves is used to identify the proper model. The application of this method to real cultivation conditions is also discussed. Using this approach, the multistage tower fermentor is shown to be equivalent to a cascade of four perfectly mixed tanks with a backtracking stream between stages. The extent of backflow under various conditions has also been determined.