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Optimal control of an enzyme reaction subject to enzyme deactivation. I. Batch process
Author(s) -
Ho Lewis Y.,
Humphrey Arthur E.
Publication year - 1970
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260120209
Subject(s) - yield (engineering) , chemistry , hydrolysis , enzyme , enzymatic hydrolysis , process (computing) , penicillin , batch processing , enzyme catalysis , chromatography , combinatorial chemistry , biochemistry , computer science , antibiotics , materials science , metallurgy , operating system , programming language
This paper is concerned with the study of an enzymatic system in a repeated batch process where the enzyme is subject to deactivation. The particular system studied was the enzymatic hydrolysis of Penicillin G to 6‐aminopenicillanic acid. Utilizing standard optimization techniques, pH and temperature control policies were determined that would maximize the product yield.