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Enzymatic brominatioin of the thiazole ring
Author(s) -
Neidleman S. L.,
Cohen A. I.,
Dean L.
Publication year - 1969
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260110616
Subject(s) - thiazole , chemistry , halogenation , ring (chemistry) , hydrogen peroxide , bromide , enzyme , stereochemistry , medicinal chemistry , organic chemistry
Bromination of the thiazole ring by the enzyme chloroperoxidase, produced by the fungus Caldariomyces fumago , was demonstrated. Both 2‐acetoacetamido‐4‐methylthiazole and 2‐acetamidothiazole were brominated on C‐5 of the thiazole ring in the presence of chloroperoxidase, bromide, and hydrogen peroxide in 0.06 M Phosphate solution at pH 3.0. No reaction occurred in the absence of enzyme.