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Erythorbic acid fermentation
Author(s) -
Takahashi Takeshi
Publication year - 1969
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260110611
Subject(s) - fermentation , yield (engineering) , chemistry , food science , biosynthesis , biochemistry , chromatography , enzyme , materials science , metallurgy
A brief review of the development of the research on erythorbic acid fermentation was presented. A previously proposed scheme of the acid biosynthesis has been proved to be correct. D‐glucono‐γ‐lactone dehydrogenase was purified to 50 fold and compared with other lactone dehydrogenases. For the purpose of commercial development, screening and mutagenie treatments of strains and studies on fundamental cultural conditions were carried out. Penicillium , but no other genera, was obtained as a producer. The experiments of ultraviolet irradiation and various cultural conditions were successful in elevating the yield of the acid over 40% in jar‐fermentor to glucose supplied. The continuous multibed extraction system of anion‐exchange resin was developed and a yield of 19.2% of the acid from fermentation broth was obtained.