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The relationship between critical oxygen level and antibiotic synthesis of capreomycin and cephalosporin C
Author(s) -
Feren C. J.,
Squires R. W.
Publication year - 1969
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260110406
Subject(s) - capreomycin , cephalosporin , cephalosporin antibiotic , oxygen , oxygen tension , chemistry , antibiotics , cephalosporin c , biochemistry , organic chemistry , streptomycin , ethambutol
This paper illustrates the type of conclusions which may be reached by the use of an electrode for measuring oxygen tension in fermentation broths. The critical oxygen level, based on oxygen uptake, and the minimum oxygen tension necessary for maximum antibiotic synthesis for two commercial antibiotic fermentations, capreomycin and cephalosporin C, were studied. Capreomycin yields were depressed at an oxygen tension which was slightly below the critical oxygen level. Cephalosporin C synthesis was depressed at an oxygen tension higher than the critical oxygen level.