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Slaframine: A parasympathomimetric from Rhizoctonia leguminicola
Author(s) -
Aust S. D.,
Broquist H. P.,
Rinehart K. L.
Publication year - 1968
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260100402
Subject(s) - rhizoctonia , metabolite , stimulation , mode of action , biology , enzyme , hay , chemistry , biochemistry , pharmacology , endocrinology , botany , rhizoctonia solani
An interesting cholinergic compound has been isolated from the fungus Rhizoctonia leguminicola grown on extracts of red clover hay . The compound was characterized as 1‐acetoxy‐8‐aminooctahydroindolizidine and given the name “slaframine.” It has been shown that slaframine is not the active compound but is converted to the active metabolite by liver microsomal enzymes. Physiological studies with slaframine point out that it is a potent stimulator of exocrine glands. In addition, its long duration of action and low toxicity suggest that it may have therapeutic value. Preliminary data suggest that slaframine is a potent stimulator of pancreatic activity, and its long duration of action results in a stimulation of protein synthesis by the gland.