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Measurement of the kinetics of biological systems at elevated temperatures utilizing flow techniques
Author(s) -
Wang Daniel IC.,
Humphrey Arthur E.,
Eagleton Lee C.
Publication year - 1964
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260060402
Subject(s) - residence time distribution , residence time (fluid dynamics) , sterilization (economics) , continuous reactor , continuous flow , kinetics , residence , biological system , process engineering , volumetric flow rate , mechanics , chemistry , thermodynamics , flow (mathematics) , materials science , environmental science , nuclear engineering , biology , physics , biochemistry , engineering , catalysis , geotechnical engineering , demography , quantum mechanics , sociology , monetary economics , economics , foreign exchange market , foreign exchange
Continuous flow‐type reactors have been used to study the kinetics of biological systems for quite some time. For continuous media sterilization, tubular flow reactors are particularly useful being simple in character and easy to control. However, one aspect quite often neglected in sterilization calculations is the residence time distribution of the reactor system. Serious errors in estimating the degree of bacterial destruction can be encountered if the residence time distribution is neglected; especially when a high degree of destruction is desired. This paper reports a study made to characterize and use the residence time distribution of a tubular reactor in the interpretation of high‐temperature, short exposure time data for inactivation of Bacillus stearothermophilus spores. Mathematical models accounting for the residence time distribution of the tubular reactor have been proposed and employed to obtain high‐temperature death‐rate data.