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Investigations of conditions for production of penicillin and chlortetracycline in submerged fermentation
Author(s) -
Matelová V.
Publication year - 1964
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260060308
Subject(s) - fermentation , chlortetracycline , laboratory flask , penicillium chrysogenum , penicillin , streptomyces aureofaciens , erlenmeyer flask , food science , chemistry , oxygen , industrial fermentation , biology , biochemistry , antibiotics , chromatography , bacteria , streptomyces , organic chemistry , genetics
During investigations of submerged fermentation of penicillin and chlortetracycline, we reached the conclusion that production in relation to oxygen transfer is relatively uninfluenced by the composition of the fermentation medium. The maximum penicillin production, using the strain Penicillium chrysogenum NG in flasks on a shaker was uniformly achieved in all investigated media with an oxygen transfer rate of 0.81; and in chlortetracycline, using strain Streptomyces aureofaciens BMK−11, with an oxygen transfer rate of 0.59 ml. O 2 /ml./hour. The primary factor which influences the antibiotics production is the transfer of oxygen into the liquid. The absolute volume of production is, however, partly influenced by mechanical conditions of fermentation and the composition of the medium.