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Biosynthesis of 7‐chloro‐6‐demethyltetracycline in the presence of certain homocysteine derivatives and methoxinine
Author(s) -
Neidleman S. L.,
Albu Evelyn,
Bienstock Evelyn
Publication year - 1963
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260050204
Subject(s) - biosynthesis , homocysteine , chemistry , plasma homocysteine , streptomyces aureofaciens , chlortetracycline , biochemistry , antibiotics , biology , bacteria , gene , streptomyces , genetics
Addition of the S ‐2‐hydroxyethyl‐, S ‐2‐chloroethyl‐, S ‐ n ‐propyl‐, and S ‐iso‐propyl‐derivatives of homocysteine, and methoxinine to S. aureofaciens (ATCC 13900) fermentations resulted in production of 7‐chloro‐6‐demethyltetracycline in addition to the normally synthesized 7‐chlortetracycline.