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Plastic ampoules for liquid smallpox vaccine
Author(s) -
Espmark Åke,
Lindner Stig
Publication year - 1962
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.260040308
Subject(s) - ampoule , smallpox vaccine , polyvinyl chloride , blow molding , welding , materials science , composite material , chemistry , vaccinia , mold , biochemistry , gene , recombinant dna
Manufacturing of plastic (PVC) single‐dose ampoules for liquid smallpox vaccine is described. The green stained vaccine is injected in polyvinyl chloride tubes which are then sealed by high frequency welding to make ampoules of 16 mm. length. The tendency for desiccation of the filled vaccine at elevated temperature is considered as an advantage, since it provides a visible indication of previous improper storage. The ampoule is opened by cutting with scissors and vaccine is squeezed out directly on the skin.