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Scaffold and scaffold‐free self‐assembled systems in regenerative medicine
Author(s) -
Thomas Dilip,
Gaspar Diana,
Sorushanova Anna,
Milcovich Gesmi,
Spanoudes Kyriakos,
Mullen Anne Maria,
O'Brien Timothy,
Pandit Abhay,
Zeugolis Dimitrios I.
Publication year - 2016
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.25869
Subject(s) - scaffold , regenerative medicine , tissue engineering , nanotechnology , computer science , materials science , biomedical engineering , biology , stem cell , microbiology and biotechnology , engineering , database
Self‐assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self‐assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self‐assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold‐free cell‐assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold‐free self‐assembled devices for regenerative medicine purposes. Biotechnol. Bioeng. 2016;113: 1155–1163. © 2015 Wiley Periodicals, Inc.