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Evaluation of a kinetic model for computer simulation of growth and fermentation by Scheffersomyces ( Pichia) stipitis fed D ‐xylose
Author(s) -
Slininger P. J.,
Dien B. S.,
Lomont J. M.,
Bothast R. J.,
Ladisch M. R.,
Okos M. R.
Publication year - 2014
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.25215
Subject(s) - pichia stipitis , xylose , fermentation , yeast , bioreactor , ethanol fuel , ethanol , chemistry , xylose metabolism , fed batch culture , ethanol fermentation , biochemistry , organic chemistry
Scheffersomyces (formerly Pichia ) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed‐batch. The model provides a summary of basic physiological yeast properties and is an important tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production. Biotechnol. Bioeng. 2014;111: 1532–1540. © 2014 Wiley Periodicals, Inc.