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In situ mixed donor synthesis of ampicillin with ethylene glycol co‐solvent
Author(s) -
Deaguero Andria L.,
Bommarius Andreas S.
Publication year - 2014
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.25143
Subject(s) - ethylene glycol , chemistry , ampicillin , solvent , yield (engineering) , in situ , ethylene , organic chemistry , catalysis , biochemistry , antibiotics , materials science , metallurgy
Ethylene glycol has the ability to act as a reactant when employed as a co‐solvent for the enzymatic synthesis of ampicillin from ( R )‐phenylglycine methyl ester and 6‐aminopenicillanic acid. The side reaction positively affects yield because its product, ( R )‐phenylglycine hydroxyethyl ester, is an intermediate for ampicillin synthesis. Biotechnol. Biotechnol. Bioeng. 2014;111: 1054–1058. © 2013 Wiley Periodicals, Inc.