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Model predicting impact of complexation with cyclodextrins on oral absorption
Author(s) -
Gamsiz Ece D.,
Thombre Avinash G.,
Ahmed Imran,
Carrier Rebecca L.
Publication year - 2013
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.24932
Subject(s) - bioavailability , absorption (acoustics) , solubility , drug , chemistry , dissolution , kinetics , drug delivery , in vivo , solubilization , biochemical engineering , chromatography , combinatorial chemistry , pharmacology , materials science , organic chemistry , biochemistry , microbiology and biotechnology , physics , medicine , composite material , quantum mechanics , engineering , biology
Significant effort and resource expenditure is dedicated to enabling low‐solubility oral drug delivery using solubilization technologies. Cyclodextrins (CD) are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. It is not clear prior to developing a drug delivery device with CD what level of absorption enhancement might be achieved; modeling can provide useful guidance in formulation and minimize resource intensive iterative formulation development. A model was developed to enable quantitative, dynamic prediction of the influence of CD on oral absorption of low solubility drug administered as a pre‐formed complex. The predominant effects of CD considered were enhancement of dissolution and slowing of precipitation kinetics, as well as binding of free drug in solution. Simulation results with different parameter values reflective of typical drug and CD properties indicate a potential positive (up to five times increase in drug absorption), negative (up to 50% decrease in absorption) or lack of effect of CD. Comparison of model predictions with in vitro and in vivo experimental results indicate that a systems‐based dynamic model incorporating CD complexation and key process kinetics may enable quantitative prediction of impact of CD delivered as a pre‐formed complex on drug bioavailability. Biotechnol. Bioeng. 2013; 110:2536–2547. © 2013 Wiley Periodicals, Inc.