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Chitosan‐heparin polyelectrolyte multilayers on cortical bone: Periosteum‐mimetic, cytophilic, antibacterial coatings
Author(s) -
Almodóvar Jorge,
Mower Justin,
Banerjee Apurba,
Sarkar Ajoy K.,
Ehrhart Nicole P.,
Kipper Matt J.
Publication year - 2013
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.24710
Subject(s) - polyelectrolyte , chitosan , heparin , periosteum , mesenchymal stem cell , chemistry , polymer , materials science , biomedical engineering , nanotechnology , surgery , biochemistry , medicine , organic chemistry , biology , microbiology and biotechnology
Cortical bone allografts suffer from high rates of failure due to poor integration with host tissue, leading to non‐union, fracture, and infection following secondary procedures. Here, we report a method for modifying the surfaces of cortical bone with coatings that have biological functions that may help overcome these challenges. These chitosan‐heparin coatings promote mesenchymal stem cell attachment and have significant antibacterial activity against both S. aureus and E. coli . Furthermore, their chemistry is similar to coatings we have reported on previously, which effectively stabilize and deliver heparin‐binding growth factors. These coatings have potential as synthetic periosteum for improving bone allograft outcomes. Biotechnol. Bioeng. 2013; 110: 609–618. © 2012 Wiley Periodicals, Inc.