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Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts
Author(s) -
Bryers James D.,
Giachelli Cecilia M.,
Ratner Buddy D.
Publication year - 2012
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.24559
Subject(s) - biocompatible material , biocompatibility , biomaterial , nanotechnology , tissue engineering , biomedical engineering , chemistry , materials science , engineering , organic chemistry
This article focuses on one of the major failure routes of implanted medical devices, the foreign body reaction (FBR)—that is, the phagocytic attack and encapsulation by the body of the so‐called “biocompatible” biomaterials comprising the devices. We then review strategies currently under development that might lead to biomaterial constructs that will harmoniously heal and integrate into the body. We discuss in detail emerging strategies to inhibit the FBR by engineering biomaterials that elicit more biologically pertinent responses. Biotechnol. Bioeng. 2012; 109:1898–1911. © 2012 Wiley Periodicals, Inc.