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Feed‐control development for succinic acid production with Anaerobiospirillum succiniciproducens
Author(s) -
Bretz Karlheinz,
Kabasci Stephan
Publication year - 2012
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.24387
Subject(s) - succinic acid , chemistry , food science , biochemistry , ethanol , yield (engineering) , metabolism , osmotic concentration , chromatography , materials science , metallurgy
The aim of this work was the development of a feed‐control for a succinic acid production fed‐batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. Based on the metabolism of Anaerobiospirillum succiniciproducens , a theoretical correlation between base consumption and glucose feed was established and proved in cultivation trials. With the established fed‐batch process, the succinic acid yield could be increased to 0.875 (g/g glucose) in comparison to batch processes (0.60) with similar glucose concentrations. Additionally, the results indicate that the osmolarity of the medium has a significant influence on succinic acid production. Biotechnol. Bioeng. 2012; 109:1187–1192. © 2011 Wiley Periodicals, Inc.