Premium
Intracellular signal transduction as a factor in the development of “Smart” biomaterials for bone tissue engineering
Author(s) -
Zambuzzi Willian F.,
Coelho Paulo G.,
Alves Gutemberg G.,
Granjeiro José M.
Publication year - 2011
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.23117
Subject(s) - microbiology and biotechnology , focal adhesion , cell adhesion , signal transduction , intracellular , integrin , tyrosine phosphorylation , adhesion , ptk2 , tyrosine kinase , chemistry , biology , cell , biochemistry , protein kinase c , mitogen activated protein kinase kinase , organic chemistry
Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell‐related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel “smart” materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation. Biotechnol. Bioeng. © 2011 Wiley Periodicals, Inc.