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Parametric sensitivity analysis and reduction of a detailed nutritional model of plant cell cultures
Author(s) -
Mailier J.,
Delmotte A.,
Cloutier M.,
Jolicoeur M.,
Wouwer A. Vande
Publication year - 2011
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.23030
Subject(s) - intracellular , biological system , biomass (ecology) , suspension culture , sensitivity (control systems) , parametric statistics , plant cell , suspension (topology) , chemistry , extracellular , nutrient , biology , biochemistry , cell culture , agronomy , mathematics , organic chemistry , genetics , statistics , engineering , electronic engineering , homotopy , gene , pure mathematics
A kinetic model of plant nutrition described by Cloutier et al. (Cloutier et al., 2008. Biotechnol Bioeng 99:189–200) is progressively simplified so as to obtain a predictive model that describes the evolution of the biomass and the extracellular and intracellular concentrations of three determining nutrients, that is, free intracellular nitrogen, phosphate, and carbohydrate compounds. Three techniques of global sensitivity analysis are successively applied to assess the model parameter influence and potential correlation. The resulting dynamic model is able to predict plant growth for the two most encountered plant bioprocesses, namely suspension cells and hairy roots. Bioeng. 2011; 108:1108–1118. © 2011 Wiley Periodicals, Inc.