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Modeling and simulation of liquid–solid circulating fluidized bed ion exchange system for continuous protein recovery
Author(s) -
Mazumder Jahirul,
Zhu Jingxu,
Bassi Amarjeet S.,
Ray Ajay K.
Publication year - 2009
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.22368
Subject(s) - fluidization , desorption , adsorption , mass transfer , chromatography , fluidized bed , materials science , fluidized bed combustion , chemistry , circulation (fluid dynamics) , ion exchange , chemical engineering , kinetics , thermodynamics , ion , organic chemistry , engineering , physics , quantum mechanics
Liquid–solid circulating fluidized bed (LSCFB) is an integrated two‐column (downcomer and riser) system which can accommodate two separate processes (adsorption and desorption) in the same unit with continuous circulation of the solid particles between the two columns. In this study, a mathematical model based on the assumption of homogeneous fluidization was developed considering hydrodynamics, adsorption‐desorption kinetics and liquid–solid mass transfer. The simulation results showed good agreement with the available experimental results for continuous protein recovery. A parametric sensitivity study was performed to better understand the influence of different operating parameters on the BSA adsorption and desorption capacity of the system. The model developed can easily be extended to other applications of LSCFB. Biotechnol. Bioeng. 2009; 104: 111–126 © 2009 Wiley Periodicals, Inc.