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Microparticles and nanoparticles for drug delivery
Author(s) -
Kohane Daniel S.
Publication year - 2006
Publication title -
biotechnology and bioengineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.136
H-Index - 189
eISSN - 1097-0290
pISSN - 0006-3592
DOI - 10.1002/bit.21301
Subject(s) - drug delivery , pharmaceutics , nanotechnology , nanoparticle , drug , pharmaceutical technology , targeted drug delivery , drug carrier , chemistry , materials science , biochemical engineering , pharmacology , medicine , chromatography , engineering
Particulate drug delivery systems have become important in experimental pharmaceutics and clinical medicine. The distinction is often made between micro‐ and nanoparticles, being particles with dimensions best described in micrometers and nanometers respectively. That size difference entails real differences at many levels, from formulation to in vivo usage. Here I will discuss those differences and provide examples of applications, for local and systemic drug delivery. I will outline a number of challenges of interest in particulate drug delivery. Biotechnol. Bioeng. 2007;96: 203–209. © 2006 Wiley Periodicals, Inc.